Write an essay on a molecular/cellular discovery that has had a significant impact on medicine. Format of Literature review but without an abstract. The topic is Inaugural Treatment for Transthyretin Amyloid Cardiomyopathy. I would suggest that you might find it easier to 1st cover the condition and then look at either the use of RNAi or tafamidis. USE ONLY TRUSTED RESOURCES SUCH AS PUBMED, NHS (for the UK),etc.
Introduction & Aims (20%): Excellent introduction that establishes the importance of work to wider knowledge, and provides a comprehensive background to the discussion. Aims clearly stated concisely and accurately without any confusion.
I would suggest keeping this under 200, certainly under 250 words. It should set out the wider picture of the molecular discovery, societal
and medical importance, and provide vital background information to give the reader context for the subsequent scientific detail. Include the aims as part
of the introduction (dont make it a separate, titled section). A few sentences on aims is fine.
Discussion (50%): This should be an in-depth scientific explanation of the biological basis of the molecular discovery covering any relevant areas. This is a good place to demonstrate critical analysis skills and good referencing.
The biological mechanisms of the molecular discovery should be excellently covered. It should be firmly rooted in scientific literature, and controversies are noted and literature is critically appraised to evaluate reliability of evidence with detail and depth.
Conclusion (10%): The conclusion should show excellent perspectives on the current state of knowledge and insight into future developments in the topic.
The conclusion should be brief: I suggest under 150 words. It should summarise the current state of knowledge from your review and also
provide some insight into future directions for research and therapy. In both cases ideally showing some personal insight of your own.
BIBLIOGRAPHY: I would aim for at least 15 citations. You should mostly cite primary research articles to defend specific facts; you can occasionally cite reviews to summarise a broad picture you do not want to go into depth on yourself.
FIGURES: A picture tells a thousand words. Use figures to illustrate key points where appropriate. Showing primary research data is fine. If you take figures
from another source, remember to cite that source. Ensure they have figure legends.
General (20%) Demonstrate superb logical flow and coherent
structure.
Professional, academic quality of
writing style, grammar and spelling.
Highly effective use of high impact
respectable and well-cited
papers that are highly appropriate
to provide excellent evidence of
claims.
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