Discuss the hypoxia-related challenges that cells face and need to overcome.- Explain the function of HIFa as an oxygen sensor, transcription factor, and translation regulator.- Explain the molecular mechanisms of translation regulation through mTOR and HIFa-dependent pathways, and compare the benefits and limitations of each pathway for the adaptation to hypoxia.- Suggest one experimental approach that could be used to determine the separate contributions of transcription and translation regulation mechanisms to the hypoxia response.- Relate the regulation mechanisms to the hypoxia-related challenges.- a diagram that highlights the function of HIFa in the cell adaptation to hypoxia through the regulation of transcription and translation. useful papers that can be used- Rocha, S. (2007). Gene regulation under low oxygen: holding your breath for transcription. Trends in Biochemical Sciences, 32(8), 389397. https://doi.org/10.1016/j.tibs.2007.06.005- Chee, N. T., Lohse, I., & Brothers, S. P. (2019). MRNA-to-protein translation in hypoxia. Molecular Cancer, 18(1), 113. https://doi.org/10.1186/s12943-019-0968-4
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