Topic: Therapeutic Effects of Vitamin D on Rheumatoid Arthritis in Adults: A Review
-Needs to be written in Arial size 10, APA style
-No abstract, introduction or conclusion is needed! Just the body with the following included: discussion section of clinical trials/supporting studies with informartion included listed below, then epidemiology of RA with attached notes included below, along with pathophysiology of RA with attached notes included below
-All studies must be Systematic reviews, meta-analyses, epidemiological, clinicaltrials,and randomized-controlled trials with peer reviewed, full-text, human studies, with age group being 18+, published between 2000-2021 are included. Narrative reviews excluded.
-Discussion Section is needed with the following included in each study found on the: Therapeutic Effects of Vitamin D on Rheumatoid Arthritis in Adults:
All supporting studies reviewed in your discussion section should include the following information:
1. Design/methodological aspects necessary to interpret the findings
2. Measures of statistical significance
3. Quantitative outcomes including magnitude of effect
4. Your evaluation of the meaning of these results (including whether the magnitude of effect is clinically meaningful)
5. Limitations/flaws
6. Relationship to the conceptual framework of the paper
Here are some that I found:
Soubrier, M., Lambert, C., Combe, B., Gaudin, P., Thomas, T., Sibilia, J., Dougados, M., & Dubost, J. J. (2018). A randomized, double-blind, placebo-controlled study assessing the efficacy of high doses of vitamin D on functional disability in patients with rheumatoid arthritis. Clinical and experimental rheumatology, 36(6), 10561060.
Yesil, H., Sungur, U., Akdeniz, S., Gurer, G., Yalcn, B., & Dundar, U. (2018). Association between serum vitamin D levels and neuropathic pain in rheumatoid arthritis patients: A cross-sectional study. International Journal of Rheumatic Diseases, 21(2), 431439.
Mateen, S., Moin, S., Shahzad, S., & Khan, A. Q. (2017). Level of inflammatory cytokines in rheumatoid arthritis patients: Correlation with 25-hydroxy vitamin D and reactive oxygen species. PloS One, 12(6), e0178879.
Hong, Q., Xu, J., Xu, S., Lian, L., Zhang, M., & Ding, C. (2014). Associations between serum 25-hydroxyvitamin D and disease activity, inflammatory cytokines, and bone loss in patients with rheumatoid arthritis. Rheumatology (Oxford, England), 53(11), 19942001.
Buondonno, I., Rovera, G., Sassi, F., Rigoni, M. M., Lomater, C., Parisi, S., Pellerito, R., Isaia, G. C., & D’Amelio, P. (2017). Vitamin D and immunomodulation in early rheumatoid arthritis: A randomized, double-blind placebo-controlled study. PloS one, 12(6), e0178463.
-Epidemiology of RA is needed on the: Therapeutic Effects of Vitamin D on Rheumatoid Arthritis in Adults:
Epidemiology is the study of factors that determine the presence or absence of illness – epidemiological research on your topic will describe the observed connections between vitamin D status and RA incidence/prevalence/severity/outcomes and will quantify the strength of those associations. This is the information that must be included.
-Pathophysiology of RA is needed on the: Therapeutic Effects of Vitamin D on Rheumatoid Arthritis in Adults:
How does vitamin D’s action in the body directly relate to the pathophysiology of RA? This should be supported by your review of individual studies, showing how this relationship is supported by the evidence (not just stating that the evidence exists or giving a citation – your appraisal of the evidence is necessary).
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